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Bupivacaine is classed as a membrane stabilising agent and is a local anaesthetic of the amide type. Marcain solutions are available with or without adrenaline, contain no antimicrobial agent and should be used only once and any residue discarded.
Marcain with adrenaline solutions for injection are sterile, isotonic aqueous solutions of bupivacaine hydrochloride in Water for Injections BP. The pH of the solution is adjusted with sodium hydroxide or hydrochloric acid to remain between 3.3-5.0. They contain sodium metabisulfite as an antioxidant.
Anhydrous bupivacaine hydrochloride (in the form of bupivacaine hydrochloride) 100.00 mg, Adrenaline 0.10 mg, Sodium chloride 160.00 mg, Sodium metabisulphite 10.00 mg, Hydrochloric acid/sodium hydroxide qs.pH=3.3 to 5.0, Water for injectable preparations qsp 20 ml.
